Look, Ma! No pneumococcus!

The Significance of Anaphylaxis in Pneumococcus Immunity

1. Intraperitoneal injections of killed and living broth cultures of a virulent pneumococcus produce in guinea pigs a high degree of active immunity and a serum with strong protective power. 2. Despite the protective power of such serum no agglutinins for the homologous organism and no precipitins for soluble derivatives were demonstrable. 3. Guinea pig immunity to pneumococcus infection produc...

Look Ma , No Hands ! Aspects of Autonomous Vehicle Control

Effect of Pneumococcus Autolysate Antitoxin on Pneumococcus Pneumonia in Guinea Pigs

1. In rabbits, guinea pigs, and mice pneumococcus autolysate antitoxin has no effect against generalized infection by the pneumococcus. 2. In a large proportion of cases of pneumonia and sepsis caused by the intratracheal inoculation of large amounts of living pneumococci in normal or sensitized guinea pigs, autolysate antitoxin saves the animal. 3. The autolysate antitoxin is protective in mos...

Effect of ampicillin and chloramphenicol against Streptococcus pneumoniae and Neisseria meningitidis.

Antagonism, determined by isobolograms constructed from data from combinations of ampicillin and chloramphenicol at or below the minimal inhibitory or bactericidal concentrations, was observed against 13 clinical isolates of meningococcus and against one isolate of pneumococcus. Synergy occurred against six strains of pneumococcus and three of meningococcus. Additive effects were noted against ...

Hydrogen Ion Concentration of Cultures of Pneumococci of the Different Types in Carbohydrate Media

1. The optimum hydrogen ion concentration for growth of pneumococcus is pH 7.8. 2. In broth cultures growth of pneumococcus continues until a final hydrogen ion concentration of about pH 5.0 is reached, if sufficient fermentable carbohydrate' (above 0.4 per cent) is present. Apparently this acidity is sufficient in itself to stop growth. 3. If less carbohydrate is present in the medium growth c...